What were you thinking Marinko??
Back when I worked for Joystiq, there was a lengthy period where I worked six-day weeks – on Saturdays I ran the website solo, as we were understaffed and there was no other way to get content onto the site other than for me to buckle down and do the work.
One Friday night, Austin and the…
Thousand-strong robot swarm throws shapes, slowly
Engineers in the US have built a swarm of 1,000 little robots that can shuffle into specific formations on command.
Each of the identical robots is given a picture of the required shape, and then they work together to make it happen. It takes up to 12 hours, but then this is the biggest throng of robots ever built and studied in this way. Inspired by biological examples, like cells forming organs or ants building bridges, the work could help develop self-assembling tools and structures. “Each robot is identical and we give them all the exact same program,” explained Dr Michael Rubenstein, the first author of the study, which is published in Science. “The only thing they have to go on, to make decisions, is what their neighbours are doing.” (via BBC News - Thousand-strong robot swarm throws shapes, slowly)
Tumor Suppressor Mutations Alone Don’t Explain Deadly Cancer
Biomarker for head and neck cancers identified
Although mutations in a gene dubbed “the guardian of the genome” are widely recognized as being associated with more aggressive forms of cancer, researchers at the University of California, San Diego School of Medicine have found evidence suggesting that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers.
The study, published online August 3 in the journal Nature Genetics, shows that high mortality rates among head and neck cancer patients tend to occur only when mutations in the tumor suppressor gene coincide with missing segments of genetic material on the cancer genome’s third chromosome.
The link between the two had not been observed before because the mutations co-occur in about 70 percent of head and neck tumors and because full genetic fingerprints of large numbers of cancer tumors have become available only recently.
“These two genetic malfunctions are not two separate stab wounds to the body,” said co-senior author Trey Ideker, PhD, chief of the Division of Genetics. “One exposes the Achilles tendon and the other is a direct blow to it.”
To patients with these cancers, the study’s results mean that there may be therapeutic value in testing tumors for the two genetic identifiers, known as a TP53 mutation (short for tumor protein 53) and a 3p deletion (short for deletions of genetic information on the short arm “p” of the third chromosome).
TP53 plays a key role in regulating cell growth, detecting and fixing DNA, and directing cell apoptosis (death) if the DNA damage is irreparable. Because of this, the TP53 protein is sometimes called the “guardian of the genome.”
The study’s findings suggest that if both markers are present, treatment should be intensified. If only one mutation is present, treatment might be de-intensified because the TP53 mutation alone is less deadly than previously thought. The latter would have immediate benefits in reducing deaths caused by complications related to medical care.
“We are in the early stages of being able to personalize head and neck cancer treatments based on the tumor’s actual biology, the same as what’s done with breast cancers,” said co-senior author Quyen Nguyen, MD, PhD, associate professor of Otolaryngology-Head and Neck Surgery. “In the past, treatments have been based largely on the size and location of the tumor. Now, we know that some large tumors may respond to less aggressive treatment while some small tumors may need intensified treatment. This will have a huge impact for patients.”
The study analyzed the complete genomic signatures of 250 cases of squamous cell head and neck cancer extracted from The Cancer Genome Atlas, a repository of sequenced cancer genomes for more than 20 different types of human cancers maintained by the National Institutes of Cancer. All of the tumors were from patients younger than 85 years of age.
Of these, 179 had both mutations; 50 had one of the two mutations; and 22 had neither mutation. Comparisons with patient outcome data showed that half of patients with both mutations would likely die of cancer within 2 years, while 66 percent of patients with one or neither mutation would be expected to live five years or more. These survival statistics were independent of the patients’ clinical cancer stage.
Besides causing cervical cancer, the human papilloma virus (HPV) is implicated in the growing epidemic of head and neck cancers in otherwise healthy adults. It is believed that the virus can co-opt the activity of TP53, affecting cells in much the same way as a TP53 mutation but without causing a mutation. For this reason, the analysis examined HPV-positive and HPV-negative tumors separately.
One of the study’s more compelling discoveries is that among HPV-positive tumors, the most aggressive cancer cases were also highly linked to the presence of 3p deletions.
“Our findings raise fundamental questions about the role of TP53 in cancer and suggest that some of the deleterious health effects of TP53 mutations might actually be due to something else going on in the third chromosome,” said lead author Andrew Gross, a graduate student in the Bioinformatics and Systems Biology Program.
Mrs Escher’s Nightmare
Demoscene production by Andromeda Software Development presents what appears to be a continuous drawing of moving 3D objects to great effect. Video embedded below, but it is preferable to experience the PC demo:
A summer demo by ASD made for Euskal Encounter 22 (2014).
Code: Konstantinos “Navis” Pataridis
Music: Sotiris “aMUSiC” Varotsis & Fotis “Leviathan” Panetsos
Hand Model and Photography: Giorgos “Ch3” Cherouvim
Graphics: Nikos “Amoivikos” Batalas
You can download the demo for PC (around 25MB) here
More at Pouet here
This thing looks like a huge thermos, and it is. By keeping rotavirus and pneumonia vaccines cold for 50 days, it saves kids’ lives. I saw it work perfectly in a rural health outpost with no running water or electricity, just an amazing health worker using technology suited to her needs.
There are coolers that keep sperm and eggs frozen for decades.
Yeah, but those coolers need electricity, something in very short supply in rural Ethiopia. (More than 60 million Ethiopians live outside or urban centers, and most of them—and most of the health centers that serve them—are without power or running water.) There are refrigerators that use propane or gas to keep cool, but propane can be expensive and difficult to keep in steady supply, so these ridiculously efficient Thermoses are (literally) a life-saver.
It’s difficult to overstate the poverty here: Most of the plowing of fields is done with wooden plows drawn by cattle, and there are almost no cars on the roads. (Most people travel by foot or on handmade carts drawn by animals). That Ethiopia has been able to reduce under-5 mortality from 25% to 8% in the past 20 years despite this poverty and a very rural population is a tremendous success story, and with effectively outfitted health posts, that percentage will get even lower—hopefully within the next decade Ethiopia’s child mortality rate will fall below the current world average of 5%.
Amazing Community Work
In the prosperity gospel, also known as the “Word of Faith,” the believer is told to use God, whereas the truth of biblical Christianity is just the opposite—God uses the believer. Word of Faith or prosperity theology sees the Holy Spirit as a power to be put to use for whatever the believer wills. The Bible teaches that the Holy Spirit is a Person who enables the believer to do God’s will. The prosperity gospel movement closely resembles some of the destructive greed sects that infiltrated the early church. Paul and the other apostles were not accommodating to or conciliatory with the false teachers who propagated such heresy. They identified them as dangerous false teachers and urged Christians to avoid them.
Paul warned Timothy about such men in 1 Timothy 6:5, 9-11. These men of “corrupt mind” supposed godliness was a means of gain and their desire for riches was a trap that brought them “into ruin and destruction” (v. 9). The pursuit of wealth is a dangerous path for Christians and one which God warns about: “For the love of money is a root of all kinds of evil. Some people, eager for money, have wandered from the faith and pierced themselves with many griefs” (v. 10). If riches were a reasonable goal for the godly, Jesus would have pursued it. But He did not, preferring instead to have no place to lay His head (Matthew 8:20) and teaching His disciples to do the same. It should also be remembered that the only disciple concerned with wealth was Judas.
Paul said covetousness is idolatry (Ephesians 5:5) and instructed the Ephesians to avoid anyone who brought a message of immorality or covetousness (Ephesians 5:6-7). Prosperity teaching prohibits God from working on His own, meaning that God is not Lord of all because He cannot work until we release Him to do so. Faith, according to the Word of Faith doctrine, is not submissive trust in God; faith is a formula by which we manipulate the spiritual laws that prosperity teachers believe govern the universe. As the name “Word of Faith” implies, this movement teaches that faith is a matter of what we say more than whom we trust or what truths we embrace and affirm in our hearts.
A favorite term in the Word of Faith movement is “positive confession.” This refers to the teaching that words themselves have creative power. What you say, Word of Faith teachers claim, determines everything that happens to you. Your confessions, especially the favors you demand of God, must all be stated positively and without wavering. Then God is required to answer (as though man could require anything of God!). Thus, God’s ability to bless us supposedly hangs on our faith. James 4:13-16 clearly contradicts this teaching: “Now listen, you who say, ‘Today or tomorrow we will go to this or that city, spend a year there, carry on business and make money.’ Why, you do not even know what will happen tomorrow. What is your life? You are a mist that appears for a little while and then vanishes.” Far from speaking things into existence in the future, we do not even know what tomorrow will bring or even whether we will be alive.
Instead of stressing the importance of wealth, the Bible warns against pursuing it. Believers, especially leaders in the church (1 Timothy 3:3), are to be free from the love of money (Hebrews 13:5). The love of money leads to all kinds of evil (1 Timothy 6:10). Jesus warned, “Watch out! Be on your guard against all kinds of greed; a man’s life does not consist in the abundance of his possessions” (Luke 12:15). In sharp contrast to the Word of Faith emphasis on gaining money and possessions in this life, Jesus said, “Do not store up for yourselves treasures on earth, where moth and rust destroy, and where thieves break in and steal” (Matthew 6:19). The irreconcilable contradictions between prosperity teaching and the gospel of our Lord Jesus Christ is best summed up in the words of Jesus in Matthew 6:24, “You cannot serve both God and money.”
On Prosperity Gospel.